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KMID : 0387420090200010059
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Korean Society of Oriental Neuropsychiatry
2009 Volume.20 No. 1 p.59 ~ p.74
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The Effects of Ondam-tanghapChongmyung-tang(Wendantanghecongmingtang) Hot Water Extract & Ultra-fine Powder on Proinflammatory Cytokine of Microglia and Memory Deficit Model
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Jang Young-Ju
Jung In-Chul
Lee Sang-Ryong
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Abstract
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Objectives: This experiment was designed to investigate the effect of the ODTCMT hot water extract & ultra-fine Powder on Alzheimer’s Disease Model Induced by βA.
Methods: The effects of the ODTCMT hot water extract on expression of IL-1β, IL-6, TNF-α in BV2 microglial cell line treated by lipopolysacchaide(LPS) were investigated. The effects of the ODTCMT hot water extract & ultra-fine powder on the behavior of the memory deficit mice induced by scopolamine were investigated.
Results: 1. The ODTCMT hot water extract significantly suppressed the production of TNF-α, IL-6 and IL-1β in BV2 microglial cell line treated with LPS. 2. The ODTCMT hot water extract & ultra-fine powder groups showed significantly inhibitory effect on the scopolamine-induced impairment of memory in the experiment of Morris water maze.
Conclusions: These results suggest that the ODTCMT hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer’s disease. Investigation into the clinical use of the ODTCMT hot water extract & ultra-fine powder for Alzheimer’s disease is suggested for future research.
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KEYWORD
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Alzheimer’s disease, Ondam-tanghapChongmyung-tang(Wendantanghecongmingtang), Hot Water Extract, Ultra-fine Powder
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